Compounded Semaglutide vs Wegovy vs Ozempic: What’s the Real Difference?
If you’re trying to choose between compounded semaglutide, Wegovy, or Ozempic, you’re not alone. These popular GLP-1 medications can aid in weight loss, but they vary in terms of price, approval, and availability. This guide breaks down the most essential facts so that you can make a confident, informed decision—fast.
What is semaglutide?
Semaglutide is a GLP-1 receptor agonist initially developed to help regulate blood sugar levels in people with type 2 diabetes. It also helps suppress appetite and slow gastric emptying, leading to significant weight loss in many patients.
It’s the active ingredient in:
- Ozempic® – approved for diabetes
- Wegovy® – approved for weight loss
- Compounded semaglutide – made by licensed pharmacies when brand-name supplies are limited
What’s the difference between compounded semaglutide, Wegovy, and Ozempic?
| Feature | Compounded Semaglutide | Wegovy® | Ozempic® |
| FDA Approved | ❌ No | ✅ Yes | ✅ Yes |
| Indication | Weight loss (off-label) | Weight loss | Type 2 diabetes |
| Availability | Made during FDA-declared shortages | Widely back in stock (as of 2024) | Available, but limited |
| Typical Price (cash pay) | $100–$400/month | $1,300+/month | $1,000–$1,200/month |
| Insurance Coverage | Rare | Rare (for obesity) | Sometimes (for diabetes) |
| Formulation | Custom-made | Standardized | Standardized |
| Injection Frequency | Weekly | Weekly | Weekly |
Bottom Line: Compounded semaglutide is not FDA-approved; however, it can be a more affordable and accessible option when brand-name versions are difficult to obtain.
What Is Compounded Semaglutide?
Compounded semaglutide is a custom-made version created by compounding pharmacies, usually mixed with B12 or other stabilizers. It’s legally allowed only during FDA-declared shortages of the brand-name drug.
Why Patients Choose It:
- Lower cost (saves 60–80%)
- Faster access during shortages
- Flexible dosing and additives like B12
Key Considerations:
- Not FDA-approved individually
- Quality varies by pharmacy.
- Must be filled at a 503A or 503B regulated facility
Is compounded semaglutide safe?
Yes, but only when prepared by a licensed or certified pharmacy specializing in compounding. During declared shortages, licensed 503A and 503B pharmacies are legally allowed to make semaglutide if:
- They use FDA-registered raw materials
- The pharmacy meets USP sterile compounding standards.
- A licensed provider prescribes the drug
Always ask for:
- Certificate of Analysis
- Pharmacy accreditation (e.g., PCAB)
- Clarity on whether it’s semaglutide base or salt
Avoid online “wellness shops” selling unlabeled or foreign products. Look for state-licensed providers, such as Anuli Med Spa, that source only from verified U.S. compounding labs.
Why is Wegovy more expensive than compounded semaglutide?
- Branding and R&D Costs – Wegovy is a patented drug by Novo Nordisk, which incurs high production and marketing expenses.
- FDA Approval Process – Branded drugs must undergo multi-year clinical trials, driving up the cost.
- Insurance Hurdles – Most policies don’t cover Wegovy for weight loss, so users pay out of pocket.
- No Competition – When supply is scarce, prices tend to rise. Compounding helps fill the gap with more affordable options.
Which is more effective: compounded semaglutide, Wegovy, or Ozempic?
The active ingredient is the same: semaglutide. So in theory, the effects are similar—if the compounded version is made accurately.
However:
- Wegovy is dosed at a higher level (up to 2.4 mg/week), which may lead to faster or greater weight loss.
- Ozempic is capped at 2 milligrams per week.
- Compounded versions can mimic either dosage, depending on your provider’s plan.
Clinical trials show:
- Wegovy users lost an average of 15% of body weight in 68 weeks
- Ozempic users lost up to 10% of their weight over a similar period.
- Compounded patients can experience similar results, but fewer controlled studies exist.
Is compounded semaglutide legal in Texas?
Yes—but only when prescribed by a licensed provider and dispensed by a Texas-registered pharmacy during an official shortage.
✅ Anuli Med Spa sources compounded semaglutide from U.S.-based, PCAB-accredited pharmacies that adhere to strict USP <797> sterile compounding guidelines.
Who should consider each option?
| You Might Choose… | If You Want… |
| Compounded Semaglutide | Lower cost, flexibility, and fast access |
| Wegovy | FDA-approved treatment for obesity, higher dosing |
| Ozempic | FDA-approved option for diabetes, possible insurance help |
Are there risks with compounded semaglutide?
Every medication carries a risk. The key concerns with compounded semaglutide are:
- Incorrect dosing from unregulated suppliers
- Improper formulation (e.g., using semaglutide salts instead of base)
- Contamination in non-sterile labs
Always confirm your provider:
- Uses licensed 503A/503B U.S. compounding pharmacies
- Provides written documentation about your compound
- Is experienced in GLP-1 weight loss programs
Can I switch between Wegovy, Ozempic, and compounded semaglutide?
Yes—under medical supervision. Many patients start with compounded semaglutide due to cost or access, then transition to a brand-name medication once insurance kicks in or supply stabilizes.
A good provider will:
- Review your weight loss history
- Monitor labs and side effects.
- Adjust dosage carefully during any switch.
FAQ: People Also Ask
Is compounded semaglutide the same as Wegovy?
No. While they share the same active ingredient, compounded semaglutide is not FDA-approved and may vary in formulation or dose.
Why is Ozempic cheaper than Wegovy?
Sometimes it is—but not always. Ozempic may be covered by insurance for the treatment of diabetes. Wegovy, which is intended for weight loss, often isn’t.
How can I tell if my compounded semaglutide is legit?
Ask your provider to show the pharmacy license, batch testing records, and whether it’s semaglutide base, not salt.
What are the side effects of semaglutide?
Nausea, constipation, fatigue, and loss of appetite are common, regardless of the brand.
Why Trust Anuli Med Spa?
✔ Experienced Providers: Our team has helped hundreds of patients safely transition between compounded and brand-name semaglutide.
✔ Transparent Pricing: No hidden fees. You’ll always know the exact cost per dose and what’s included.
✔ Verified Pharmacies: We only use licensed U.S. compounders who meet FDA and PCAB standards.
✔ Customized Plans: Our dosing strategy strikes a balance between safety, efficacy, and cost, tailored to your specific needs.
Get Expert Help Choosing the Right GLP-1 Option
Whether you’re navigating shortages or trying to compare the fundamental differences between compounded semaglutide, Wegovy, and Ozempic, Anuli Med Spa makes the process easier.
Call (713) 555-0212 or Book Online to schedule your consultation today.
Nneka “Adaeze” Anyanwu, MSN, FNP-C, blends board-certified clinical mastery with a passion for luxury wellness at Anuli Aesthetics & Weightloss. Trained in pharmacology and cosmetic science and fellowship-certified in aesthetic medicine, she designs evidence-based weight-loss and body-sculpting programs for high-achieving women who demand results.